GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs683250 | 1 | rs558104 | chr11:83276244 | CCDC90B | chr11:82972506-82997414:- | 0.17 | 3.97 | 8.36E-5 | Subcortical brain region volumes |
| THCA | cis | rs55821258 | 1 | rs55821258 | chr8:96292041 | C8orf37 | chr8:96258235-96281437:- | 0.29 | 3.87 | 0.000126 | 3-hydroxy-1-methylpropylmercapturic acid levels in smokers |
| THCA | cis | rs13191362 | 1 | rs55822577 | chr6:163069710 | PACRG | chr6:163148164-163736523:+ | 0.52 | 7.21 | 2.27E-12 | Body mass index |
| THCA | cis | rs1552244 | 1 | rs55822690 | chr3:10128003 | C3orf10 | chr3:10157333-10168873:+ | -0.2 | -4.24 | 2.72E-5 | Alzheimer's disease |
| THCA | cis | rs1552244 | 1 | rs55822690 | chr3:10128003 | VHL | chr3:10183319-10193744:+ | -0.18 | -4.11 | 4.6E-5 | Alzheimer's disease |
| THCA | cis | rs7107174 | 1 | rs55825352 | chr11:78034424 | NARS2 | chr11:78147017-78285909:- | -0.4 | -6.99 | 9.16E-12 | Testicular germ cell tumor |
| THCA | cis | rs4959799 | 1 | rs55829773 | chr6:3291397 | PSMG4 | chr6:3259162-3268300:+ | -0.33 | -5.53 | 5.34E-8 | Survival in rectal cancer |
| THCA | cis | rs4372836 | 1 | rs55835850 | chr2:28949296 | PPP1CB | chr2:28974612-29025805:+ | -0.17 | -4.23 | 2.81E-5 | Body mass index |
| THCA | cis | rs4372836 | 1 | rs55835850 | chr2:28949296 | TRMT61B | chr2:29072690-29093175:- | 0.5 | 10.02 | 1.36E-21 | Body mass index |
| THCA | cis | rs12188164 | 1 | rs55842567 | chr5:437586 | C5orf55 | chr5:441645-443258:- | 0.33 | 8.44 | 3.87E-16 | Cystic fibrosis severity |
| THCA | cis | rs983392 | 1 | rs55847558 | chr11:59903793 | MS4A14 | chr11:60145958-60185226:+ | 0.16 | 4.24 | 2.65E-5 | Alzheimer's disease (late onset) |
| THCA | cis | rs13191362 | 1 | rs55847707 | chr6:163003414 | PACRG | chr6:163148164-163736523:+ | 0.46 | 7.08 | 5.13E-12 | Body mass index |
| THCA | cis | rs2129782 | 1 | rs55848977 | chr8:89444200 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |
| THCA | cis | rs7537765 | 1 | rs55857306 | chr1:11895795 | CLCN6 | chr1:11866207-11907674:+ | 0.16 | 3.51 | 0.000496 | QRS complex (12-leadsum) |
| THCA | cis | rs6499255 | 1 | rs55863174 | chr16:69819996 | COG4 | chr16:70514473-70557457:- | -0.19 | -3.93 | 9.78E-5 | IgE levels |